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Zoloft belongs to a class of drugs called selective serotonin reuptake inhibitors and the other drugs in this class are Prozac Paxil Celexa and Luvox. Serotonin is a neurotransmitter produced by nerve cells in our brain that is used by the nerves to communicate with one another. A nerve produces the serotonin it produces into the space surrounding it. The serotonin either moved across the space and attaches to receptors on the surface of nearby nerves or it attaches to receptors on the surface of the nerve that produced it, to be taken up by the nerve and released again. Equilibrium is reached for serotonin between attachment to the nearby nerves and reuptake. Selective serotonin inhibitors block the reuptake of serotonin and therefore alter the level of serotonin in the brain.
It is believed that some diseases such as depression are caused by disturbances in the balance between serotonin and other neurotransmitters. The primary theory is that drugs such as sertraline restore the chemical balance among neurotransmitters in the brain. The Food and Drug Administration approved sertraline in December 1991. Sertraline is used for treating depression, panic disorder, obsessive-compulsive disorder and post-traumatic stress disorder. Sertraline also is indicated for treating postmenstrual dysphoric disorder and social anxiety disorder .
Serious reactions such as hyperthermia, fluctuations in blood pressure and rigidity of muscles may occur when SSRIs are used in combination with monoamine oxidase inhibitors such as phenelzine, tranylcypromine and isocarboxazid. Therefore, SSRIs should not be used in combination with MAOIs and in addition, SSRIs and MAOIs should not be used within 14 days of each other.
Cimetidine may increase the levels in blood of sertraline by reducing the elimination of sertraline by the liver. Increased levels of sertraline may lead to more adverse effects.
Sertraline increases the blood level of pimozide by 40%. High levels of pimozide can affect electrical conduction in the heart and would lead to sudden death. Therefore, patients should not receive treatment with both sertraline and pimozide..
Through unknown process, sertraline may increase the blood thinning action of warfarin. The effect of warfarin should be closely monitored when sertraline is started or stopped.